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Merck
CN

14-685-M

Cdk9/Cyclin T1 Protein, active, 10 µg

Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

Key Documents

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Product Name

Cdk9/Cyclin T1 Protein, active, 10 µg, Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.

biological source

human

recombinant

expressed in Sf9 cells

mol wt

Mw 44 kDa (cdk9)
Mw 80.79 kDa (cyclinT1)

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_001261.2

UniProt accession no.

P50750

Quality Level

100

Gene Information

human ... CDK9(1025)

Analysis Note

routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: CDK9/cyclin T1
Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
Product Source: expressed by baculovirus in Sf21 insect cells

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Ni2+/NTA-agarose

Preparation Note

stable for 6 months at -70°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
Sano, Motoaki and Schneider, Michael D
Cell Cycle, 2, 99-104 (2003)
Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Garriga, Judit and Gra?a, Xavier
Gene, 337, 15-23 (2004)
Li-Ying Liou et al.
The international journal of biochemistry & cell biology, 36(9), 1767-1775 (2004-06-09)
The macrophage is an important cell type in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection. Macrophages both support viral replication and are capable of attracting and activating lymphocytes, thus rendering CD4+ T lymphocytes highly permissive for infection.
Tinggui Yin et al.
Molecular cancer therapeutics, 13(6), 1442-1456 (2014-04-02)
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CTD. Given the reported dysregulation of

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