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Merck
CN

14-692-M

DAPK1 Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human DAPK1, amino acids 1-296, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

Key Documents

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Product Name

DAPK1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human DAPK1, amino acids 1-296, for use in Kinase Assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 60.9 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_004938.2

UniProt accession no.

P53355

Quality Level

100
300

Gene Information

human ... DAPK1(1612)

Analysis Note

routinely evaluated by phosphorylation of ZIPtide (Catalog #12-545)

Biochem/physiol Actions

Protein Target: DAPK1

General description

N-terminal GST-tagged, recombinant, human DAPK1, amino acids 1-296

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme

Preparation Note

stable 6 months at -70°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anastasia V Velentza et al.
Pharmacology & therapeutics, 93(2-3), 217-224 (2002-08-23)
Death-associated protein kinase (DAPK) is a calmodulin-regulated serine/threonine protein kinase associated with neuronal cell death in animal models of disease. The recent determination of the 1.5A crystal structure of the catalytic kinase domain of DAPK, the discovery of amino acid
The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.
Shohat, Galit, et al.
Biochimica et Biophysica Acta, 1600, 45-50 (2002)
Epigenetic change in pituitary tumorigenesis.
Farrell, W E and Clayton, R N
Endocrine-Related Cancer, 10, 323-330 (2003)
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death.
Bialik, Shani and Kimchi, Adi
Seminars in cancer biology, 14, 283-294 (2004)

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