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171264

AMPK Inhibitor, Compound C•2HCl

Name: AMPK Inhibitor, Compound C•2HCl
Brand: MM

InSolution, ≥98%

Synonym(s):

InSolution AMPK Inhibitor, Compound C•2HCl, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I, AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₅N₅O

CAS Number:

866405-64-3

Molecular Weight:

399.49

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD08705402

Assay:

≥98% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

shipped in

ambient

storage temp.

−20°C

SMILES string

[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI key

XHBVYDAKJHETMP-UHFFFAOYSA-N

Description

General description

A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No.123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.

Packaging

Packaged under inert gas

Physical form

A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.

Preparation Note

Following intial thaw, aliquot and freeze (-20°C).

Other Notes

Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c