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About This Item
Empirical Formula (Hill Notation):
C73H118N16O27
Molecular Weight:
1651.81
UNSPSC Code:
12352202
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
aqueous buffer, pH 7.5: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC50 = 30 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
APP
APP
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM against amyloid precursor protein (APP) β-secretase
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]
Sinha, S., et al. 1999. Nature 402, 537.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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