176695
Angeli′s Salt
A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.
Synonym(s):
Angeli’s Salt, Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
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About This Item
Empirical Formula (Hill Notation):
N2O3 · 2Na
CAS Number:
Molecular Weight:
121.99
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥99%
Form:
crystalline solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥99%
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
alkaline solution: soluble (0.01 M NaOH)
shipped in
wet ice
storage temp.
−20°C
General description
A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Nitroxyl anion (NO-) donor
Nitroxyl anion (NO-) donor
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
Other Notes
Miranda, K.M., et al. 2001. J. Biol. Chem.276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol.110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol.131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol.268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun.196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem.34, 3242.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol.110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol.131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol.268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun.196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem.34, 3242.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 176695-10MG | 04055977222951 |