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Merck
CN

19-123-M

Staurosporine

protein kinase C inhibitor

Synonym(s):

PKC inhibitor, protein kinase C inhibitor

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405

Key Documents

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Product Name

Staurosporine, Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

Quality Level

100

Related Categories

Analysis Note

Routinely evaluated by Protein Kinase Inhibition Assay

Application

Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.

Biochem/physiol Actions

Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.

General description

Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

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Joachim Rudolph et al.
The Enzymes, 34 Pt. B, 157-180 (2013-01-01)
The p21-activated kinases (PAKs) are Ser/Thr kinases in the STE20 kinase family with important roles in regulating cytoskeletal organization, cell migration, and signaling. The PAK enzyme family comprises six members subdivided into two groups: Group I, represented by PAK1, 2
Carl D Bortner et al.
Methods in enzymology, 428, 161-181 (2007-09-19)
The loss of cell volume or cell shrinkage, termed apoptotic volume decrease (AVD), is a classical characteristic of apoptosis. Microscopy, Coulter electronic sizing, and/or flow cytometry has traditionally been the means to measure this characteristic of apoptosis. Although electronic cell
Yasuko Nakajima et al.
Methods in enzymology, 484, 613-630 (2010-11-03)
Electrophysiological experiments in our laboratory have led to the discovery that the cholinergic neurons in the nucleus basalis in the rat forebrain possess constitutively active inward rectifier K(+) channels. Unlike cloned inward rectifier K(+) channels, these constitutively active inward rectifier
Boyang Chen et al.
Bioelectrochemistry (Amsterdam, Netherlands), 153, 108456-108456 (2023-05-30)
Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of events that eventually lead
Staurosporine: a prototype of a novel class of inhibitors of tumor cell invasion?
C A O'Brian et al.
Journal of the National Cancer Institute, 82(22), 1734-1735 (1990-11-21)

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