20-265
Dithiothreitol, 1M
Synonym(s):
2,3-Butanediol, 1,4-dimercapto-, Cleland′s reagent, Sputolysin
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About This Item
UNSPSC Code:
41116012
NACRES:
NA.41
eCl@ss:
32160405
Application
Dithiothreitol, 1M may be used as a reducing agent in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) loading buffer. It may also be used as a reagent in saliva sterilization.
Biochem/physiol Actions
Dithiothreitol (DTT), also known as Cleland′s reagent, is a reducing agent containing two thiol functional groups. It serves as a protective regent for thiol groups in protein chemistry studies. DTT is used in chemical peptide synthesis for reducing disulfide bonds in various substrates such as glutathione, proteins, and other macromolecules. It is also used as a mucolytic agent during sputum processing.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
8A - Combustible corrosive hazardous materials
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Certificates of Analysis (COA)
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I S Woolhouse et al.
Thorax, 57(8), 667-671 (2002-08-01)
Sputum analysis is used increasingly to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis. However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 99, 1022-1032 (2018-01-09)
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