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Merck
CN

203303

Bisindolylmaleimide V

A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM).

Synonym(s):

Bisindolylmaleimide V, 2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045, 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045

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About This Item

Empirical Formula (Hill Notation):
C21H15N3O2
CAS Number:
113963-68-1
Molecular Weight:
341.36
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-orange

solubility

DMSO: 10 mg/mL
methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3

InChI key

SWAWYMIKGOHZMR-UHFFFAOYSA-N

General description

A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6kin vivo (IC50 8 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Negative control compound for protein kinase C inhibition
Product does not compete with ATP.
Reversible: no
Target IC50: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

Other Notes

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Stephen R Reeves et al.
Experimental physiology, 92(6), 1057-1066 (2007-08-07)
Protein kinase C (PKC) is a broadly expressed and critically important signalling protein with a wide range of functional roles, including central components of respiratory control. For example, systemic and targeted administration of PKC inhibitors within the nucleus of the

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