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203350

Blasticidin S hydrochloride

Name: Blasticidin S hydrochloride
Brand: MM

from Streptomyces griseochromogenes, ≥98% (HPLC), powder, protein syntheis inhibitor, Calbiochem^®

Synonym(s):

Blasticidin S, Hydrochloride, Streptomyces griseochromogenes

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₆N₈O₅ · xHCl

CAS Number:

3513-03-9

Molecular Weight:

422.44 (free base basis)

UNSPSC Code:

51286700

NACRES:

NA.77

MDL number:

MFCD02091640

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

Blasticidin S, Hydrochloride, Streptomyces griseochromogenes,

assay

≥98% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white to off-white

shipped in

ambient

storage temp.

2-8°C

SMILES string

Cl.N2(C=CC(=NC2=O)N)[C@@H]1O[C@@H]([C@H](C=C1)NC(=O)C[C@@H](N)CCN(C)\C(=N\[H])\N)C(=O)O

InChI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1

InChI key

YQXYQOXRCNEATG-NMQKUDMSSA-N

Description

General description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase genes (bsr from Bacillus cereus or BSD from Aspergillus terreus), whose products convert blasticidin S to a non-toxic deaminohydroxy derivative.

Biochem/physiol Actions

Primary Target
protein synthesis

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions (pH ≤7) are stable for up to 1 year at -20°C. Avoid alkaline pH. Do not subject to freeze/thaw cycles; upon thawing any aliquots, discard the unused portion.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kimura, M., et al. 1994. Biochim. Biophys. Acta1219, 653.
Kimura, M., et al. 1994, Mol. Gen. Genet.242, 121.
Kojima, N., et al. 1994. J. Biol. Chem.269, 30451.
Kudo, T., et al. 1994. J. Immunol. Methods177, 17.
Sutoh, K. 1993. Plasmid30, 150.
Izumi, M., et al. 1991. Exp. Cell Res.197, 229.
Yamaguchi, H., et al. 1965. J. Biol. Chem.57, 667.
Takeuchi, S., et al. 1958. J. Antibiot.11, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H300

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Precautionary Statements

P264 - P270 - P301 + P310 + P330 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

Flash Point (°F)

No data available

Flash Point (°C)