203694
bpV(bipy)
A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).
Synonym(s):
bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
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About This Item
Linear Formula:
K[VO(O2)2C10H8N2] · 3H2O
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (51V-NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (51V-NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow to orange
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent inhibitor of phosphotyrosine phosphatase activity (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
phosphotyrosine phosphatase
phosphotyrosine phosphatase
Product does not compete with ATP.
Reversible: no
Target IC50: 18 nM against PTEN
Target Ki: 100 nM for phosphotyrosine phosphatase
Packaging
Packaged under inert gas
Preparation Note
Unstable in solution; reconstitute just prior to use.
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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