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Merck
CN

203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

Synonym(s):

bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV

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About This Item

Linear Formula:
K[VO(O2)2C10H8N2] · 3H2O
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

bpV(bipy), A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

assay

≥95% (51V-NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow to orange

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Target Ki: 100 nM for phosphotyrosine phosphatase
Reversible: no
Target IC50: 18 nM against PTEN
Primary Target
phosphotyrosine phosphatase
Product does not compete with ATP.
Cell permeable: no

Disclaimer

Toxicity: Harmful (C)

General description

A potent inhibitor of phosphotyrosine phosphatase activity (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).

Other Notes

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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