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About This Item

Empirical Formula (Hill Notation):
C10H10BrN5O7P · Na
CAS Number:
51116-01-9
Molecular Weight:
446.08
MDL number:
MFCD00070128
UNSPSC Code:
41106305
NACRES:
NA.77
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Product Name

Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt, Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

water: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4[nH]c(n[c](c4nc3Br)=O)N)CO1)O

InChI

1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1

InChI key

YUFCOOWNNHGGOD-UMMCILCDSA-N

General description

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
protein kinase G
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.

Other Notes

Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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