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203890-M

CRAC Channel Inhibitor, BTP2

Name: CRAC Channel Inhibitor, BTP2
Brand: MM

The CRAC Channel Inhibitor, BTP2, also referenced under CAS 223499-30-7, controls the biological activity of CRAC Channel. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

CRAC Channel Inhibitor, BTP2, [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], TPRC3 Channel Inhibitor II, Pyr2

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₉F₆N₅OS

CAS Number:

223499-30-7

Molecular Weight:

421.32

UNSPSC Code:

12352200

MDL number:

MFCD00220976

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

solubility

DMSO: 5 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)NC(=O)c3[s]nnc3C

InChI

1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)

InChI key

XPRZIORDEVHURQ-UHFFFAOYSA-N

Description

General description

A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca²⁺ release-activated Ca²⁺) channel-mediated SOCE (store-operated Ca²⁺ entry) in RBL-2H3 cells (IC₅₀ = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca²⁺ entry) inTRPC3-expressing HEK293 cells (IC₅₀ = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca²⁺ signaling studies.

Biochem/physiol Actions

Primary Target
CRAC Channel

Target IC₅₀: 590 nM by Fura-2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Schleifier, H., et al. 2012. Br J PharmacolIn Press
Yonetoku, Y., et al. 2006. Bioorg. Med. Chem.14, 5370.
Yonetoku, Y., et al. 2006. Bioorg. Med. Chem.14, 4750.
Zitt, C., et al. 2004. J. Biol. Chem.279, 12927.
Trevillyan, J.M., et al. 2001. J. Biol. Chem.276, 48118.
Djuric, S.W., et al. 2000. J. Med. Chem.43, 2975.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c