205531
CA-074 Me
≥98% (HPLC), solid, Cathepsin B inhibitor, Calbiochem®
Synonym(s):
CA-074 Me, Cathepsin B Inhibitor IV, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
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About This Item
Empirical Formula (Hill Notation):
C19H31N3O6
Molecular Weight:
397.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze
Product Name
CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable analog of CA-074 (Cat. No. 205530 ) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
Target IC50: 2.24 nM against cathepsin B
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sever, N., et al. 2002. Biol. Chem.383, 839.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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