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COA/COQ

208734

Calmodulin Binding Domain

Name: Calmodulin Binding Domain
Brand: MM

Potent calmodulin antagonist.

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Synonym(s):

Calmodulin Binding Domain, Calmodulin antagonist, CaM kinase II 290-309

Empirical Formula (Hill Notation):

C₁₀₃H₁₈₅N₃₁O₂₄S

CAS Number:

115044-69-4

Molecular Weight:

2273.83

MDL number:

MFCD00076719

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C103H185N31O24S/c1-17-58(10)80(98(154)131-75(50-57(8)9)97(153)133-82(63(15)136)100(156)134-81(62(14)135)99(155)126-72(39-46-159-16)92(148)127-73(48-55(4)5)93(149)119-61(13)101(157)158)132-84(140)59(11)117-79(138)53-116-86(142)66(33-21-25-40-104)122-95(151)74(49-56(6)7)128-90(146)68(35-23-27-42-106)124-89(145)71(38-30-45-115-103(112)113)125-88(144)70(37-29-44-114-102(110)111)120-83(139)60(12)118-94(150)77(52-78(109)137)130-96(152)76(51-64-31-19-18-20-32-64)129-91(147)69(36-24-28-43-107)123-87(143)67(34-22-26-41-105)121-85(141)65(108)47-54(2)3/h18-20,31-32,54-63,65-77,80-82,135-136H,17,21-30,33-53,104-108H2,1-16H3,(H2,109,137)(H,116,142)(H,117,138)(H,118,150)(H,119,149)(H,120,139)(H,121,141)(H,122,151)(H,123,143)(H,124,145)(H,125,144)(H,126,155)(H,127,148)(H,128,146)(H,129,147)(H,130,152)(H,131,154)(H,132,140)(H,133,153)(H,134,156)(H,157,158)(H4,110,111,114)(H4,112,113,115)/t58-,59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,80-,81-,82-/m0/s1

InChI key

LRKHMNPQPYICFK-RBGVSSEXSA-N

General description

A potent calmodulin antagonist that inhibits Ca²⁺/calmodulin-dependent protein kinase II (IC₅₀ = 52 nM) and Ca²⁺/calmodulin-dependent phosphodiesterase (IC₅₀ = 1.1 nM).

Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC₅₀ = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Calmodulin dependent Protein Kinase-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 52 nM against calmodulin-dependent protein kinase II

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.

Other Notes

James, P., et al. 1995. Trends Biochem. Sci.20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem.270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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