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Merck
CN

208734

Calmodulin Binding Domain

Potent calmodulin antagonist.

别名:

Calmodulin Binding Domain, Calmodulin antagonist, CaM kinase II 290-309

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关于此项目

经验公式（希尔记法）:
C103H185N31O24S
化学文摘社编号:
115044-69-4
分子量:
2273.83
UNSPSC Code:
12352202
MDL number:
MFCD00076719

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InChI

1S/C103H185N31O24S/c1-17-58(10)80(98(154)131-75(50-57(8)9)97(153)133-82(63(15)136)100(156)134-81(62(14)135)99(155)126-72(39-46-159-16)92(148)127-73(48-55(4)5)93(149)119-61(13)101(157)158)132-84(140)59(11)117-79(138)53-116-86(142)66(33-21-25-40-104)122-95(151)74(49-56(6)7)128-90(146)68(35-23-27-42-106)124-89(145)71(38-30-45-115-103(112)113)125-88(144)70(37-29-44-114-102(110)111)120-83(139)60(12)118-94(150)77(52-78(109)137)130-96(152)76(51-64-31-19-18-20-32-64)129-91(147)69(36-24-28-43-107)123-87(143)67(34-22-26-41-105)121-85(141)65(108)47-54(2)3/h18-20,31-32,54-63,65-77,80-82,135-136H,17,21-30,33-53,104-108H2,1-16H3,(H2,109,137)(H,116,142)(H,117,138)(H,118,150)(H,119,149)(H,120,139)(H,121,141)(H,122,151)(H,123,143)(H,124,145)(H,125,144)(H,126,155)(H,127,148)(H,128,146)(H,129,147)(H,130,152)(H,131,154)(H,132,140)(H,133,153)(H,134,156)(H,157,158)(H4,110,111,114)(H4,112,113,115)/t58-,59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,80-,81-,82-/m0/s1

InChI key

LRKHMNPQPYICFK-RBGVSSEXSA-N

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).
Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Calmodulin dependent Protein Kinase-2
Product does not compete with ATP.
Reversible: no
Target IC50: 52 nM against calmodulin-dependent protein kinase II

Packaging

Yes

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.

Other Notes

H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
James, P., et al. 1995. Trends Biochem. Sci.20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem.270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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