Skip to Content
Merck
CN

Key Documents

View All Documentation

211875

Captopril

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM).

Synonym(s):

Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C9H15NO3S
CAS Number:
62571-86-2
Molecular Weight:
217.29
UNSPSC Code:
12352200
MDL number:
MFCD00168073
Assay:
≥98% (titration)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

General description

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
An antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

Biochem/physiol Actions

Cell permeable: no
Primary Target
ACE
Product does not compete with ATP.
Reversible: yes
Target IC50: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

Other Notes

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Still not finding the right product?

Explore all of our products under Captopril

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
211875-1GM04055977219197