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Merck
CN

218745

Caspase Inhibitor III

The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase Inhibitor III, Boc-D-FMK

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About This Item

Empirical Formula (Hill Notation):
C11H18FNO5
CAS Number:
634911-80-1
Molecular Weight:
263.26
MDL number:
MFCD04038181
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

100

form

semisolid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

FCC(=O)C(NC(=O)OC(C)(C)C)CC(=O)OC

InChI

1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)

InChI key

MXOOUCRHWJYCAL-UHFFFAOYSA-N

Related Categories

General description

A broad-spectrum cell-permeable and irreversible caspase inhibitor.
A cell-permeable, irreversible, broad-spectrum caspase inhibitor.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
broad spectrum caspase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 4 months at 4°C or for up to 1 year at -20°C.

Analysis Note

single spot by TLC

Other Notes

Boc-Asp(OMe)-CH₂F*
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
D’Mello, S.R., et al. 1998. J. Neurochem. 70, 1809.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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