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Merck
CN

218861

Sigma-Aldrich

Casein Kinase II Inhibitor III, TBCA

InSolution, ≥90%

Synonym(s):

InSolution Casein Kinase II Inhibitor III, TBCA, ( E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

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About This Item

Empirical Formula (Hill Notation):
C9H4Br4O2
CAS Number:
934358-00-6
Molecular Weight:
463.74
MDL number:
MFCD20921901
UNSPSC Code:
12352200
NACRES:
NA.54

Key Documents

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Quality Level

100

Assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

shipped in

dry ice

storage temp.

−70°C

SMILES string

OC(/C=C/C1=CC(Br)=C(Br)C(Br)=C1Br)=O

InChI

1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+

InChI key

SVJQCVOKYJWUBC-OWOJBTEDSA-N

Related Categories

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
CKII
Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup - (refers to pure substance)

Flash Point(C)

87 °C - closed cup - (refers to pure substance)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mario A Pagano et al.
Chembiochem : a European journal of chemical biology, 8(1), 129-139 (2006-11-30)
Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7-tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy toward

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