218861
Casein Kinase II Inhibitor III, TBCA
InSolution, ≥90%
别名:
InSolution Casein Kinase II Inhibitor III, TBCA, ( E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
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关于此项目
经验公式（希尔记法）:
C9H4Br4O2
化学文摘社编号:
分子量:
463.74
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
InChI
1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
SMILES string
OC(/C=C/C1=CC(Br)=C(Br)C(Br)=C1Br)=O
InChI key
SVJQCVOKYJWUBC-OWOJBTEDSA-N
assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
shipped in
dry ice
storage temp.
−70°C
Quality Level
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General description
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CKII
CKII
Reversible: yes
Packaging
Packaged under inert gas
Physical form
A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Pagano, M.A., et al. 2006. Chembiochem,8, 129.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (refers to pure substance)
flash_point_c
87 °C - closed cup - (refers to pure substance)
Mario A Pagano et al.
Chembiochem : a European journal of chemical biology, 8(1), 129-139 (2006-11-30)
Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7-tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy toward
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