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Merck
CN

219379

Cathepsin K Inhibitor II

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin K Inhibitor II, Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc

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About This Item

Empirical Formula (Hill Notation):
C35H51N7O8
Molecular Weight:
697.82
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

Cathepsin K Inhibitor II, The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cathepsin K
Product does not compete with ATP.
Reversible: yes
Target Ki: 6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

Other Notes

Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Wang, D., et al. 2002. Biochemistry41, 8849.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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