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Merck
CN

219392

Cathepsin B Substrate III, Fluorogenic

≥95% (HPLC), lyophilized solid, Cathepsin B inhibitor, Calbiochem®

Synonym(s):

Cathepsin B Substrate III, Fluorogenic, Z-RR-AMC, 2HCl

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About This Item

Empirical Formula (Hill Notation):
C30H39N9O6 · 2HCl
Molecular Weight:
694.61
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
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Product Name

Cathepsin B Substrate III, Fluorogenic, Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.

Quality Level

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

DMSO: 5 mg/mL, water: soluble

fluorescence

λex 360-380 nm, λem 430-460 nm

shipped in

ambient

storage temp.

−20°C

General description

Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity (excitation maximum: 380 nm; emission maximum: 460 nm).

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Other Notes

Hiwasa, T., et al. 1987. FEBS Lett.211, 23.
Manson, R.W., et al. 1985. Biochem. J.226, 233.
Tanaka, M., et al. 1985. Life Sci. 36, 1217.
Docherty, K., et al. 1984. J. Biol. Chem.259, 6041.
Barrett, A.J., and Kirschke, H. 1981. Methods Enzymol.80, 535.
Barrett, A.J. 1980. Biochem. J.187, 909.
Z-Arg-Arg-AMC, 2HCl

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)


Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

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Lin Cui et al.
Frontiers in cell and developmental biology, 8, 31-31 (2020-03-03)
Lysosomal membrane permeabilization (LMP) has recently been recognized as an important cell death pathway in various cell types. However, studies regarding the correlation between LMP and cardiomyocyte death are scarce. Lysosomal membrane-associated protein 2 (Lamp2) is an important component of



Global Trade Item Number

SKUGTIN
219392-25MG04055977201673