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Merck
CN

219478

Cdk4 Inhibitor III

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Cdk4 Inhibitor III, 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine

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About This Item

Empirical Formula (Hill Notation):
C15H12N2O2S
CAS Number:
265312-55-8
Molecular Weight:
284.33
MDL number:
MFCD09971103
UNSPSC Code:
12352200
NACRES:
NA.77

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SMILES string

[s]1c2c(nc1C)C(=O)C(=CC2=O)Nc3ccc(cc3)C

InChI

1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3

InChI key

HFPLHASLIOXVGS-UHFFFAOYSA-N

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

black-purple

solubility

DMSO: 10 mg/mL

shipped in

ambient

Quality Level

100

Related Categories

General description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cdk4
Product does not compete with ATP.
Reversible: no
Target IC50: 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett.10, 461.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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