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Merck
CN

23-027-M

b-catenin Protein, activated, 10 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Synonym(s):

Catenin beta-1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405

Key Documents

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Product Name

b-catenin Protein, activated, 10 µg, Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

biological source

human

recombinant

expressed in Sf21 cells

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_001904

Quality Level

100
300

Application

Ubiquitination Cascade Comoponent: Substrate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Purified using immobilized metal affinity chromatography.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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?-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
Schade, Babette, et al.
Cancer Research, 73, 4474-4487 (2013)

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