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Merck
CN

230752

Chromomycin A3

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 to distinguish chromosomes by their total DNA content and DNA base composition.

Synonym(s):

Chromomycin A3, Toyomycin

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About This Item

Empirical Formula (Hill Notation):
C57H82O26
CAS Number:
7059-24-7
Molecular Weight:
1183.25
UNSPSC Code:
12352200
MDL number:
MFCD00043151

Key Documents

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Quality Level

100

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1

InChI key

ZYVSOIYQKUDENJ-WKSBCEQHSA-N

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

ethanol: 10 mg/mL

fluorescence

λex ~445 nm, λem ~575 nm

General description

Antibiotic that inhibits RNA synthesis by way of DNA-dependent RNA polymerase. Fluorescent dye that can be used in conjunction with Bisbenzimide H33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA (Mg2+ required) but does not intercalate the A:T pairs, which preferentially bind Bisbenzimide H33258.
Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA content and DNA base composition. Reversibly interacts with DNA in the presence of Mg2+. Binds to G:C pairs of helical DNA but does not intercalate.

Preparation Note

Following recosntitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Aich, P., et al. 1992. Biochemistry31, 2988.
Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA89, 4913.
Van Dilla, M.A., et al. 1983. Science220, 620.
Mizuno, K. 1963. J. Antibiot.16, 22.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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