230790
Chymostatin
Selective neurokinin-1 (NK1) receptor antagonist, solid,powder
Synonym(s):
Chymostatin, [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A = Leu; B = Val; or C = Ile]-phenylalaninal
Product Name
Chymostatin, Contains chymostatin "A" as a major form.
Quality Level
description
RTECS - GC3047700
form
powder
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to slightly yellow
solubility
5% glacial acetic acid: 10 mg/mL
DMSO: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N7C(CCNC7=N)[C@H](NC(=O)N[C@@H](Cc9ccccc9)C(=O)O)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](Cc8ccccc8)C=O.N4C(CCNC4=N)[C@H](NC(=O)N[C@@H](Cc6ccccc6)C(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc5ccccc5)C=O.N1C(CCNC1=N)[C@H](NC(=O)N[C@@H](Cc3ccccc3)C(=O)O)C(=O)N[C@@
InChI
1S/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1
InChI key
QJIJPLFVFWXMGK-KSPFWWQASA-N
Related Categories
General description
Product does not compete with ATP.
Reversible: No
Chymostatin is a naturally occurring inhibitor of serine proteases with chymotryptic-like specificity. This tetrapeptide inhibitor is produced by various species of Streptomyces bacteria. Chymostatin is used as an inhibitor of MC chymase and is also capable of inhibiting several other proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, and lysosomal cysteine proteinases such as cathepsins B, H, andL. Itcontains chymostatin "A" as a major form.
Application
- cysteine protease inhibitor in thesubstrate to measure the activated FX (FXa) activity
- protease inhibitor in enzyme purificationlysis buffer
- protease inhibitor for ISW2 protein complexpurification
Legal Information
Disclaimer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service