Skip to Content
Merck
CN

233156

Cleland′s Reagent, Molecular Biology Grade

A protective agent for SH groups.

Synonym(s):

Cleland’s Reagent, Molecular Biology Grade, 1,4-Dithiothreitol, DTT

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C4H10O2S2
CAS Number:
Molecular Weight:
154.25
UNSPSC Code:
12161504
NACRES:
NA.25
MDL number:
Assay:
≥99% (titration)
Form:
powder, solid
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


grade

Molecular Biology

Quality Level

description

Merck USA index - 14, 3376

assay

≥99% (titration)

form

powder, solid

reaction suitability

reagent type: reductant

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 15 mg/mL

cation traces

heavy metals: ≤0.001%

absorption

≤0.100 at 280 nm at 100 mM (1 cm), ≤0.500 at 260 nm at 100 mM (1 cm)

foreign activity

DNases, proteases, RNases, none detected

shipped in

ambient

storage temp.

2-8°C

SMILES string

SC[C@H](O)[C@@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChI key

VHJLVAABSRFDPM-IMJSIDKUSA-N

General description

A protective agent for SH groups.
Water-soluble protective reagent for sulfhydryl groups [absorbance (100 mM): ≤0.5 at 260 nm; ≤0.1 at 280 nm]. It is capable of maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. Since it readily permeates cell membranes, it can protect protein sulfhydryls and restore enzyme activity lost by oxidation.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)


pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Global Trade Item Number

SKUGTIN
233156-10GM04055977217759
233156-1GM07790788054281