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233165

Clioquinol

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

Synonym(s):

Clioquinol, 5-Chloro-7-iodo-8-hydroxyquinoline

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About This Item

Empirical Formula (Hill Notation):
C9H5ClINO
CAS Number:
130-26-7
Molecular Weight:
305.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00006787
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Quality Level

100

description

Merck USA index - 14, 5031

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

ethanol: 1 mg/mL, methanol: 1.5 mg/mL, DMSO: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Ic1c(c2ncccc2c(c1)Cl)O

InChI

1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChI key

QCDFBFJGMNKBDO-UHFFFAOYSA-N

General description

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that reduces the build-up of these deposits. Exhibits greater affinity for Cu2+ and Zn2+ than for Ca2+ and Mg2+. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Metal ion chelator
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Melov, S. 2002. Trends Neurosci.25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.
Helmuth, L., et al. 2000. Science290, 1273.
Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
233165-1GM04055977217766