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Clodronate disodium Salt

Name: Clodronate disodium Salt
Brand: MM

≥97% (titration), bone resorption inhibitor, solid

Synonym(s):

Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

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About This Item

Empirical Formula (Hill Notation):

CH₂Cl₂Na₂O₆P₂ · 4H₂O

CAS Number:

88416-50-6

Molecular Weight:

360.92

MDL number:

MFCD02940846

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (titration)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

Clodronate, Disodium Salt, A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

Quality Level

100

description

Merck USA index - 14, 2371

assay

≥97% (titration)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O

InChI

1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2

InChI key

XWHPUCFOTRBMGS-UHFFFAOYSA-L

Description

General description

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Osteoclast-mediated bone resorption

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

Other Notes

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c