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251400

D609 Potassium Salt

Name: D609 Potassium Salt
Brand: MM

≥98% (HPLC), Phosphatidylcholine-specific phospholipase C inhibitor, powder

Synonym(s):

D609, Potassium Salt, Tricyclodecan-9-yl-xanthogenate, K

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₅OS₂ · K

CAS Number:

83373-60-8

Molecular Weight:

266.46

UNSPSC Code:

41106500

NACRES:

NA.77

MDL number:

MFCD00171401

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

D609, Potassium Salt, Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM).

Quality Level

100

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

DMSO: 25 mg/mL, water: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[K].SC(=S)OC1C2C3C(C(C2)C1)CCC3

InChI

1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);

InChI key

YFUFHKMDCZBHMY-UHFFFAOYSA-N

Description

General description

Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, K_i= 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A₂, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
pc-specificphopholipase c

Product does not compete with ATP.

Reversible: no

Target K_i: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C

Preparation Note

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

Other Notes

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c