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Merck
CN

286888

BHQ

Mobilizes Ca2+ specifically from Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity.

Synonym(s):

BHQ, 2,5-Di-( t-butyl)-1,4-hydroquinone, t-BuBHQ, 2,5-Di-(t-butyl)-1,4-hydroquinone, t-BuBHQ

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About This Item

Empirical Formula (Hill Notation):
C14H22O2
CAS Number:
88-58-4
Molecular Weight:
222.32
UNSPSC Code:
12352200
MDL number:
MFCD00008825
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

Key Documents

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InChI

1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3

InChI key

JZODKRWQWUWGCD-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mM, ethanol: 25 mg/mL, methanol: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: no
Primary Target
micosomal and sarcoplasmic reticulation Ca2+ ATPase activity
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.

Other Notes

Salvador, J.M., and Mata, A.M. 1998. Arch. Biochem. Biophys. 351, 272.
Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540.
Khan, Y.M., et al. 1995. Biochemistry 34, 14385.
Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118.
Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167.
Schilling, W.P., et al. 1992. Biochem. J.284, 521.
Wictome, M., et al. 1992. FEBS Lett.304, 109.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.
Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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