288500-M
DL-α-Difluoromethylornithine, Hydrochloride
A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.
Synonym(s):
DL-α-Difluoromethylornithine, Hydrochloride, DFMO, Eflornithine, RMI-71782
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About This Item
Empirical Formula (Hill Notation):
C6H12F2N2O2 · xHCl · yH2O
CAS Number:
Molecular Weight:
182.17 (anhydrous free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
description
Merck USA index - 14, 3522
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL, methanol: 25 mg/mL
storage temp.
10-30°C
SMILES string
FC(F)C(N)(CCCN)C(=O)O.[Cl-].O.[H+]
InChI
1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChI key
FJPAMFNRCFEGSD-UHFFFAOYSA-N
General description
A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
Biochem/physiol Actions
Primary Target
ODC
ODC
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
Takigawa, M., et al. 1990. Cancer Res.50, 4131.
Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
Danzin, C., et al. 1979. Life Sci. 24, 519.
Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
Takigawa, M., et al. 1990. Cancer Res.50, 4131.
Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
Danzin, C., et al. 1979. Life Sci. 24, 519.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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