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317240

Metformin

≥97% (titration), solid, AMPK signaling activator, Calbiochem®

Synonym(s):

Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII

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About This Item

Empirical Formula (Hill Notation):
C4H11N5 · xHCl
CAS Number:
1115-70-4
Molecular Weight:
129.16 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00012582
Assay:
≥97% (titration)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)
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Product Name

Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

Quality Level

100

description

Merck USA index - 14, 5938

assay

≥97% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

Cl.N(C)(C)C(=N\C(=N\[H])\N)N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

General description

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

Biochem/physiol Actions

Cell permeable: no
Primary Target
AMP-activated protein kinase (AMPK)
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
317240-5GM04055977216196