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Merck
CN

317505

1,2-Dioctanoyl-sn-glycerol

Cell-permeable activator of protein kinase C (PKC).

Synonym(s):

1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV

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About This Item

Empirical Formula (Hill Notation):
C19H36O5
CAS Number:
60514-48-9
Molecular Weight:
344.49
MDL number:
MFCD00036835
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

1,2-Dioctanoyl-sn-glycerol, Cell-permeable activator of protein kinase C (PKC).

SMILES string

O([C@H](COC(=O)CCCCCCC)CO)C(=O)CCCCCCC

InChI

1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1

InChI key

ZQBULZYTDGUSSK-KRWDZBQOSA-N

description

RTECS - RH0764500

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

clear colorless

solubility

chloroform: soluble
ethyl acetate: soluble

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Analysis Note

Single spot by TLC

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Protein kinase C
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKCα than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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