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Merck
CN

324740

Elastase Substrate V, Fluorogenic

≥95% (HPLC), powder, lyophilized solid, elastase substrate, Calbiochem®

Synonym(s):

Elastase Substrate V, Fluorogenic, MeOSuc-AAPV-AMC

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About This Item

Empirical Formula (Hill Notation):
C31H41N5O9
CAS Number:
72252-90-5
Molecular Weight:
627.69
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
MFCD00077135

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Product Name

Elastase Substrate V, Fluorogenic, Elastase Substrate V, Fluorogenic, CAS 72252-90-5, is a sensitive fluorogenic substrate for the quantitative determination of human leukocyte and porcine pancreatic elastase (Km = 140 µM).

SMILES string

N1([C@@H](CCC1)C(=O)NC(=O)[C@@H](Nc2cc3c(cc2)C(=CC(=O)O3)C)C(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)OC)C)C

InChI

1S/C31H41N5O9/c1-16(2)27(34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)30(42)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27,34H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,35,41,42)/t18-,19-,22-,27-/m0/s1

InChI key

NHMQNKPYBPDCAY-NFHWZJRKSA-N

assay

≥95% (HPLC)
≥95% (TLC)

form

lyophilized solid
powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white to off-white

solubility

ethanol: 1 mg/mL
DMF: 5 mg/mL
DMSO: 5 mg/mL

fluorescence

λex 360-380 nm
λem 430-460 nm

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Related Categories

Biochem/physiol Actions

Cell permeable: no
Km = 140 µM; kcat/Km = 120,000 M⁻¹ s⁻¹as substrates for human leukocyte and porcine pancreatic elastase
Primary Target
Sensitive fluorogenic substrate for the quantitative determination of human leukocyte and porcine pancreatic elastase
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Sensitive fluorogenic substrate for the quantitative determination of human leukocyte (Km = 140 µM; Kcat/Km = 120,000 s-1 M-1) and porcine pancreatic elastase. Not hydrolyzed by cathepsin G. Excitation max.: ~380 nm; emission max.: ~460 nm.

Other Notes

Barrett, A.J. 1981. Methods Enzymol. 80, 581.
Castillo, M.J., et al. 1979. Anal. Biochem.99, 53.
Nakajima, K., et al. 1979. J. Biol. Chem.254, 4027.
MeOSuc-Ala-Ala-Pro-Val-AMC

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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