Skip to Content
Merck
CN

324813

Soluble Epoxide Hydrolase Inhibitor, NCND

The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.

Synonym(s):

Soluble Epoxide Hydrolase Inhibitor, NCND, CDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C19H38N2O
CAS Number:
402939-18-8
Molecular Weight:
310.52
MDL number:
MFCD01344729
UNSPSC Code:
12352202
NACRES:
NA.54

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

N(C1CCCCC1)C(=O)NCCCCCCCCCCCC

InChI

1S/C19H38N2O/c1-2-3-4-5-6-7-8-9-10-14-17-20-19(22)21-18-15-12-11-13-16-18/h18H,2-17H2,1H3,(H2,20,21,22)

InChI key

POEWFBSYPFIYSK-UHFFFAOYSA-N

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

dichloromethane: 1 mg/mL

shipped in

ambient

Quality Level

100

Related Categories

General description

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC50 = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.
A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC50 = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Soluble epoxide hydrolase
Product competes with ATP.
Reversible: no
Target IC50: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA100, 1558.
Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.
Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.
Imig, J.D., et al. 2002. Hypertension39, 690.
Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.
Yu, Z., et al. 2000. Circ. Res.87, 992.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service