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329600

Erastin

≥98% (HPLC), solid, ferroptosis inducer, Calbiochem®

Synonym(s):

Erastin, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one

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About This Item

Empirical Formula (Hill Notation):
C30H31ClN4O4
CAS Number:
571203-78-6
Molecular Weight:
547.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09837984
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Product Name

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

General description

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yagoda, N., et al. 2007. Nature447, 864.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Eikan Mishima et al.
Nature, 619(7968), E9-E18 (2023-07-06)
Natalie K Horvat et al.
ACS nano, 18(17), 11025-11041 (2024-04-17)
ALK-positive NSCLC patients demonstrate initial responses to ALK tyrosine kinase inhibitor (TKI) treatments, but eventually develop resistance, causing rapid tumor relapse and poor survival rates. Growing evidence suggests that the combination of drug and immune therapies greatly improves patient survival;
Zhuhui Yuan et al.
Oxidative medicine and cellular longevity, 2022, 3403009-3403009 (2022-10-21)
Ionizing radiation-derived oxidative stress and ferroptosis are one of the most important biological effects on destroying the liver tumor, whereas radioresistance of liver tumor remains a leading cause of radiotherapy (RT) failure mainly because of the protective antiferroptosis, in which
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Global Trade Item Number

SKUGTIN
329600-5MG04055977195651