330200-M
Ecotin, E. coli
A potent, broad range inhibitor of serine proteases.
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (SDS-PAGE)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles
Quality Segment
assay
≥90% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
storage temp.
−70°C
General description
A potent, broad range inhibitor of serine proteases.
A potent, broad range inhibitor or serine proteases. Exhibits picomolar binding constant for the inhibition of chymotrypsin, elastase, Factor Xa, Factor XIIa, kallikrein, and trypsin. Also an effective inhibitor of collagenase and granzyme B.
Biochem/physiol Actions
Primary Target
serine proteases
serine proteases
Product does not compete with ATP.
Target IC50: 1 pM against serine proteases
binds trypsin in the picomolar range
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 1.0 mM HCl.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
McGrath, M.E., et al. 1995. Protein Sci. 4, 141.
Seong, I.S., et al. 1994. J. Biol. Chem. 269, 21915.
McGrath, M.E., et al. 1991. J. Biol. Chem. 266, 6620.
Seong, I.S., et al. 1994. J. Biol. Chem. 269, 21915.
McGrath, M.E., et al. 1991. J. Biol. Chem. 266, 6620.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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