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341305

Fasentin

Name: Fasentin
Brand: MM

Synonym(s):

Fasentin, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide, Glucose Transporter Inhibitor, Glucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₉ClF₃NO₂

CAS Number:

392721-37-8

Molecular Weight:

279.64

UNSPSC Code:

12352200

NACRES:

NA.54

MDL number:

MFCD01001285

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥95% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

FC(F)(F)c1c(ccc(c1)NC(=O)CC(=O)C)Cl

InChI

1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)

InChI key

GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Description

General description

A cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED₅₀ = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.

Other Notes

Wood, T.E., et al. 2008. Mol. Cancer Ther.7, 3546
Schimmer, A.D., et al. 2006. Cancer Res.66, 2367.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c