Skip to Content
Merck
CN

Key Documents

View All Documentation

341310

FABP4 Inhibitor

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

Synonym(s):

FABP4 Inhibitor, adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C31H26N2O3
CAS Number:
300657-03-8
Molecular Weight:
474.55
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09991687
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200
Storage condition:
OK to freeze, protect from light
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 20 mg/mL, DMSO: 50 mg/mL, methanol: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]3(nc(c(c3CC)c5ccccc5)c4ccccc4)c1c(cccc1)c2cc(ccc2)OCC(=O)O

InChI

1S/C31H26N2O3/c1-2-27-30(22-12-5-3-6-13-22)31(23-14-7-4-8-15-23)32-33(27)28-19-10-9-18-26(28)24-16-11-17-25(20-24)36-21-29(34)35/h3-20H,2,21H2,1H3,(H,34,35)

InChI key

SJRVJRYZAQYCEE-UHFFFAOYSA-N

General description

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = <2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP′s (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Furuhashi, M., et al. 2007. Nature447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chunyan Yu et al.
Cancer immunology, immunotherapy : CII, 69(1), 115-126 (2019-12-06)
Pro-inflammatory cytokines are crucial mediators of cancer development, representing potential targets for cancer therapy. The molecular mechanism of a vital pro-inflammatory cytokine, IL-17A, in cancer progression and its potential use in therapy through influencing fatty acid (FA) metabolism, especially FA
Sanjay Basak et al.
Cell biology international, 44(5), 1237-1251 (2020-02-20)
Curcumin has a protective role in placental diseases like preeclampsia and preterm birth. Very little is known about its functional effects on growth, angiogenesis, and epigenetic activities of human first trimester placenta. HTR8/SVneo trophoblasts cells were used as model for
Qiuyuan Zhu et al.
Cell biology international, 39(5), 540-547 (2015-01-13)
The aims of this study were to delineate the expression of fatty-acid binding protein (FABP) 4 in human uterine endometrium and its function in the regulation of proliferation, migration and invasion of epithelial cells. Immunohistochenistry, immunofluorence and Western blotting were

Global Trade Item Number

SKUGTIN
341310-5MG04055977215656