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About This Item

Empirical Formula (Hill Notation):
C22H26N4O2
CAS Number:
959626-45-0
Molecular Weight:
378.47
MDL number:
MFCD10568148
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N4(CCCCC4)c1c(cc(cc1)N3CCCCC3)NC(=O)c2[o]c(cc2)C#N

InChI

1S/C22H26N4O2/c23-16-18-8-10-21(28-18)22(27)24-19-15-17(25-11-3-1-4-12-25)7-9-20(19)26-13-5-2-6-14-26/h7-10,15H,1-6,11-14H2,(H,24,27)

InChI key

FQGXFVDABCBEFW-UHFFFAOYSA-N

General description

A cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive cFMS/CSF-1R inhibitor that blocks cFMS autophosphorylation both in CSF-1/M-CSF-stimulated HEK-293 cells (IC50 = 76 nM) and in cell-free in vitro kinase assays (IC50 = 17 nM).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Patch, R.J., et al. 2007. Bioorg. Med. Chem. Lett.17, 6070.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Certificates of Analysis (COA)

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