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Merck
CN

344845

Fumagillin, Aspergillus fumigatus

Antiprotozoal agent and angiogenesis inhibitor.

Synonym(s):

Fumagillin, Aspergillus fumigatus

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About This Item

Empirical Formula (Hill Notation):
C26H34O7
CAS Number:
23110-15-8
Molecular Weight:
458.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD03990453

Key Documents

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Product Name

Fumagillin, Aspergillus fumigatus, Antiprotozoal agent and angiogenesis inhibitor.

SMILES string

O1[C@@](C1CC=C(C)C)([C@@H]2[C@]3(OC3)CC[C@H]([C@H]2OC)OC(=O)\C=C\C=C\C=C\C=C\C(=O)O)C

InChI

1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1

InChI key

NGGMYCMLYOUNGM-IJIYPQOHSA-N

description

Merck USA index - 14, 4286

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
Methionine amino-peptidase 2
Product does not compete with ATP.

Disclaimer

Toxicity: Harmful (C)

General description

An inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC50 = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.
Antiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.

Other Notes

Zhang, P., et al. 2002. J. Biomed. Sci.9, 34.
Stepien, H., et al. 1996. J. Endocrinol.150, 99.
Abrams, J.S., et al. 1994. Cancer74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol.6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem.36, 762.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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