344935
Furin Substrate, Fluorogenic
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).
Synonym(s):
Furin Substrate, Fluorogenic
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About This Item
Empirical Formula (Hill Notation):
C37H57N13O9
Molecular Weight:
827.93
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 10 mg/mL, DMSO: soluble
fluorescence
λex 360 - 380 nm, λem 430-460 nm
shipped in
ambient
storage temp.
−20°C
General description
A fluorogenic substrate for furin (kcat/Km ~2 X 104 M-1 s-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (kcat/Km ~6 X 103 M-1 s-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 104 s-1M-1).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Fluorogenic substrate for furin
Fluorogenic substrate for furin
Product does not compete with ATP.
Reversible: no
kcat/Km ~ 2 x 104 s-1M-1 for furin
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lamango, N.S., et al. 1996. Arch. Biochem. Biophys.330, 238.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Pyr-Arg-Thr-Lys-Arg-AMC
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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