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345670

Galanthamine, Hydrobromide

Name: Galanthamine, Hydrobromide
Brand: MM

A competitive and reversible inhibitor of acetylcholinesterase.

Synonym(s):

Galanthamine, Hydrobromide, Nivalin, HBr

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₁NO₃ · xHBr

CAS Number:

69353-21-5

Molecular Weight:

287.35 (free base basis)

MDL number:

MFCD05734759

UNSPSC Code:

12352116

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated

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Properties

Quality Level

100

description

Merck USA index - 14, 4340

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

ethanol: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Br-].[N+H]1(CC[C@@]32[C@@H](Oc4c3c(ccc4OC)C1)C[C@H](C=C2)O)C

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChI key

QORVDGQLPPAFRS-XPSHAMGMSA-N

Description

General description

A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.

Cholinesterase antagonist. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Acetylcholinesterase

Product competes with ATP.

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Pilger, C., et al. 2001. J. Mol. Graph. Model19, 288.
Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
Southan, G.J., et al. 1996. Br. J. Pharmacol.117, 619.
Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c