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Merck
CN

345670

Galanthamine, Hydrobromide

A competitive and reversible inhibitor of acetylcholinesterase.

Synonym(s):

Galanthamine, Hydrobromide, Nivalin, HBr

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About This Item

Empirical Formula (Hill Notation):
C17H21NO3 · xHBr
CAS Number:
69353-21-5
Molecular Weight:
287.35 (free base basis)
MDL number:
MFCD05734759
UNSPSC Code:
12352116
NACRES:
NA.77

Key Documents

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Product Name

Galanthamine, Hydrobromide, A competitive and reversible inhibitor of acetylcholinesterase.

SMILES string

[Br-].[N+H]1(CC[C@@]32[C@@H](Oc4c3c(ccc4OC)C1)C[C@H](C=C2)O)C

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChI key

QORVDGQLPPAFRS-XPSHAMGMSA-N

description

Merck USA index - 14, 4340

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

ethanol: 1 mg/mL
water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Acetylcholinesterase
Product competes with ATP.
Reversible: yes

Disclaimer

Toxicity: Toxic (F)

General description

A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.
Cholinesterase antagonist. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Pilger, C., et al. 2001. J. Mol. Graph. Model19, 288.
Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
Southan, G.J., et al. 1996. Br. J. Pharmacol.117, 619.
Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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