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Merck
CN

351801

Glucose Transporter Inhibitor III, STF-31

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Synonym(s):

Glucose Transporter Inhibitor III, STF-31, STF-31

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About This Item

Empirical Formula (Hill Notation):
C23H25N3O3S
Molecular Weight:
423.53
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD04153828

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SMILES string

[S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C

InChI key

NGQPRVWTFNBUHA-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

Quality Level

100

Related Categories

General description

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

flash_point_c

Not applicable

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

Certificates of Analysis (COA)

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