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Merck
CN

36-006

Anti-phospho-CPI-17 (Thr38) Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-phospho-CPI-17 (Thr38) Antibody, Upstate®, from rabbit

biological source

rabbit

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, bovine, human, pig, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

isotype

IgG

NCBI accession no.

NM_033256.1

UniProt accession no.

Q96A00

shipped in

dry ice

target post-translational modification

phosphorylation (pThr38)

Quality Level

100

Gene Information

bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)

Analysis Note

Routinely evaluated by immunoblot on phosphorylated recombinant CPI-17.

Application

Detect phospho-CPI-17 (Thr38) using this Anti-phospho-CPI-17 (Thr38) Antibody validated for use in EA.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Biochem/physiol Actions

CPI-17 phosphorylated on Threonine 38.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

~17 kDa

Immunogen

Peptide corresponding to amino acids 35-46 of human CPI-17.

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%.
Format: Purified
Protein A purified

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Information

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Ketrija Touw et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G66-G76 (2011-10-08)
Seventy-six percent of diabetic patients develop gastrointestinal symptoms, such as constipation. However, the direct effects of diabetes on intestinal smooth muscle are poorly described. This study aimed to identify the role played by smooth muscle in mediating diabetes-induced colonic dysmotility.
Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.
Mahavadi, S; Bhattacharya, S; Kumar, DP; Clay, C; Ross, G; Akbarali, HI; Grider, JR; Murthy, KS
American Journal of Physiology: Gastrointestinal and Liver Physiology null
T Kitazawa et al.
The Journal of biological chemistry, 275(14), 9897-9900 (2000-04-01)
Myosin light chain phosphatase (MLCP) plays a pivotal role in smooth muscle contraction by regulating Ca(2+) sensitivity of myosin light chain phosphorylation. A smooth muscle phosphoprotein called CPI-17 specifically and potently inhibits MLCP in vitro and in situ and is
Ayça Toprak Semiz et al.
Life sciences, 255, 117834-117834 (2020-05-27)
Hydrogen sulfide (H2S) is shown in ocular tissues and suggested to involve in the regulation of retinal circulation. However, the mechanism of H2S-induced relaxation on retinal artery is not clarified yet. Herein, we aimed to evaluate the role of several
Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor
Eto, M., et al
Neuron, 36, 1145-1158 (2002)
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