36-006
Anti-phospho-CPI-17 (Thr38) Antibody
Upstate®, from rabbit
登录 查看组织和合同定价。
选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
rabbit, bovine, human, pig, mouse, rat
Application:
activity assay
Citations:
17
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rabbit, bovine, human, pig, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pThr38)
Quality Level
Gene Information
bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)
General description
~17 kDa
Immunogen
Peptide corresponding to amino acids 35-46 of human CPI-17.
Application
Detect phospho-CPI-17 (Thr38) using this Anti-phospho-CPI-17 (Thr38) Antibody validated for use in EA.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Biochem/physiol Actions
CPI-17 phosphorylated on Threonine 38.
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%.
Format: Purified
Protein A purified
Preparation Note
2 years at -20°C
Analysis Note
Routinely evaluated by immunoblot on phosphorylated recombinant CPI-17.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
新产品
此项目有
T Kitazawa et al.
The Journal of biological chemistry, 275(14), 9897-9900 (2000-04-01)
Myosin light chain phosphatase (MLCP) plays a pivotal role in smooth muscle contraction by regulating Ca(2+) sensitivity of myosin light chain phosphorylation. A smooth muscle phosphoprotein called CPI-17 specifically and potently inhibits MLCP in vitro and in situ and is
Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.
Mahavadi, S; Bhattacharya, S; Kumar, DP; Clay, C; Ross, G; Akbarali, HI; Grider, JR; Murthy, KS
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Ketrija Touw et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G66-G76 (2011-10-08)
Seventy-six percent of diabetic patients develop gastrointestinal symptoms, such as constipation. However, the direct effects of diabetes on intestinal smooth muscle are poorly described. This study aimed to identify the role played by smooth muscle in mediating diabetes-induced colonic dysmotility.
Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation.
Ohki, S, et al.
Journal of Molecular Biology, 314, 839-849 (2001)
Karen A Fagan et al.
American journal of physiology. Lung cellular and molecular physiology, 287(4), L656-L664 (2004-02-24)
RhoA GTPase mediates a variety of cellular responses, including activation of the contractile apparatus, growth, and gene expression. Acute hypoxia activates RhoA and, in turn, its downstream effector, Rho-kinase, and previous studies in rats have suggested a role for Rho/Rho-kinase
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持