生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
rabbit, bovine, human, pig, mouse, rat
制造商/商品名称
Upstate®
技术
activity assay: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pThr38)
基因信息
bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)
一般描述
~17 kDa
免疫原
Peptide corresponding to amino acids 35-46 of human CPI-17.
应用
Detect phospho-CPI-17 (Thr38) using this Anti-phospho-CPI-17 (Thr38) Antibody validated for use in EA.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
生化/生理作用
CPI-17 phosphorylated on Threonine 38.
外形
Protein A purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%.
Format: Purified
制备说明
2 years at -20°C
分析说明
Routinely evaluated by immunoblot on phosphorylated recombinant CPI-17.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
法规信息
新产品
此项目有
T Kitazawa et al.
The Journal of biological chemistry, 275(14), 9897-9900 (2000-04-01)
Myosin light chain phosphatase (MLCP) plays a pivotal role in smooth muscle contraction by regulating Ca(2+) sensitivity of myosin light chain phosphorylation. A smooth muscle phosphoprotein called CPI-17 specifically and potently inhibits MLCP in vitro and in situ and is
Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.
Mahavadi, S; Bhattacharya, S; Kumar, DP; Clay, C; Ross, G; Akbarali, HI; Grider, JR; Murthy, KS
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Ketrija Touw et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G66-G76 (2011-10-08)
Seventy-six percent of diabetic patients develop gastrointestinal symptoms, such as constipation. However, the direct effects of diabetes on intestinal smooth muscle are poorly described. This study aimed to identify the role played by smooth muscle in mediating diabetes-induced colonic dysmotility.
Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation.
Ohki, S, et al.
Journal of Molecular Biology, 314, 839-849 (2001)
Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor
Eto, M., et al
Neuron, 36, 1145-1158 (2002)
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