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361515

Glycogen Phosphorylase Inhibitor

Name: Glycogen Phosphorylase Inhibitor
Brand: MM

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

Synonym(s):

Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₅ClF₂N₄O₄

CAS Number:

648926-15-2

Molecular Weight:

412.78

MDL number:

MFCD22050364

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1c(cc(c(c1)Cl)C(=O)NC(=O)Nc2c(ccc(c2)NC(=O)NC)OC)F

InChI

1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)

InChI key

ROJNYKZWTOHRNU-UHFFFAOYSA-N

Description

General description

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC₅₀ = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC₅₀ = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Glycogen phosphorylase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 53 nM against glycogen phosphorylase

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c