Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C22H20FN3O2
Molecular Weight:
377.41
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange-yellow
solubility
DMSO: 100 mg/mL
DMSO: soluble
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Schmole, AC., et al. 2010. Bioorg. Med. Chem.18, 6785.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service