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Merck
CN

368055

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO

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About This Item

Empirical Formula (Hill Notation):
C21H34N4O10
CAS Number:
1258003-96-1
Molecular Weight:
502.52
MDL number:
MFCD01318858
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Granzyme B Inhibitor II, The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

InChI key

AXTKTZHLZLOIIO-WBOIFEBMSA-N

SMILES string

N([C@@H]([C@@H](O)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)[C@H](CC)C)CCC(=O)O

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 1 nM against caspase-8

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Potent, reversible granzyme B and caspase-8 inhibitor.

Other Notes

Ac-Ile-Glu-Thr-Asp-CHO
Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Abdulla Berjis et al.
Nature communications, 15(1), 3937-3937 (2024-05-11)
Human natural killer (NK) cell-based therapies are under assessment for treating various cancers, but cryopreservation reduces both the recovery and function of NK cells, thereby limiting their therapeutic feasibility. Using cryopreservation protocols optimized for T cells, here we find that

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