368055
Granzyme B Inhibitor II
The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
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About This Item
Empirical Formula (Hill Notation):
C21H34N4O10
CAS Number:
Molecular Weight:
502.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze
Quality Segment
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@@H]([C@@H](O)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)[C@H](CC)C)CCC(=O)O
InChI key
AXTKTZHLZLOIIO-WBOIFEBMSA-N
General description
A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Potent, reversible granzyme B and caspase-8 inhibitor.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 1 nM against caspase-8
Other Notes
Ac-Ile-Glu-Thr-Asp-CHO
Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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