368059-M
Granzyme B Substrate II, Fluorogenic
A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.
Synonym(s):
Granzyme B Substrate II, Fluorogenic, Z-IETD-AFC, Caspase-8 Substrate II
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About This Item
Empirical Formula (Hill Notation):
C37H42F3N5O13
Molecular Weight:
821.75
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 1 mg/mL
fluorescence
λex ~400 nm, λem ~505 nm
storage temp.
−20°C
Quality Level
General description
A fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
Biochem/physiol Actions
Primary Target
Fluorogenic substrate for the detection of granzyme B and caspase-8 activity
Fluorogenic substrate for the detection of granzyme B and caspase-8 activity
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
Z-Ile-Glu-Thr-Asp-AFC
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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